Although great progress has been made on reducing smoking rates over past decades, smoking remains one of the most important preventable causes of morbidity and mortality in the Australian population. There is good evidence that opportunistic intervention GPs can substantially increase abstinence rates and deliver significant public health benefits. However, there are a number of known barriers to initiating a discussion about smoking cessation. GP registrars need to develop an efficient and effective approach to this topic, including understanding the range of pharmacological interventions available.