Polypharmacy is the concurrent use of multiple medications. This is an issue for all patients with comorbidities, although most prominent in the elderly, with a recent MJA study finding that 66% of people aged 75+ years taking five or more medications. Polypharmacy can be associated with multiple side effects, interactions and patient harm. De-prescribing is the process of withdrawal of an inappropriate or redundant medication with the goal of managing polypharmacy and improving outcomes. This tutorial is linked to the supervision activity of prescribing audit and feedback.